Immune System Balance and Flexibility in Maintaining Good Oral Health

Immune System Balance and Flexibility in Maintaining Good Oral Health

The immune system is highly dynamic and flexible, changing in reaction to the surrounding environment. While it is well known that the immune system fights infection and cancers, including those of the dental, oral, and craniofacial region, it is less clear how it functions in the balance between oral health and oral disease. This initiative supports research to understand how the immune system remains flexible to maintain good oral health, both in the absence and presence of disease or injury, in order to develop new treatment strategies.

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Early programming of the immune system

The immune system is constructed to enable a very broad, almost infinite ability to respond to antigenic challenges, including those derived from the oral microbiome related to periodontitis and caries. This concept has been described as the immunobiography of each individual and is a composite of challenges and responses early in life that may program the immune system for the characteristics of responses later in life. ...more »

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Changes to the antigenic ecospace in disease

The antigenic ecospace can be defined as "the universe of antigens that [have] driven [immune system] evolution.(1) How this ecospace changes on the individual level during the initiation and progression of disease, such as periodontitis, and how the individual host immune capacity reacts to these changes remains ill-defined. Reference 1. Capri M, Salvioli S, Monti D, Bucci L, Garagnani P, Ottaviani E, Franceschi C. ...more »

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Biological aging and immune responses in the oral cavity

While work on immune responses in the oral cavity and studies of periodontitis have demonstrated changes with aging, it is not clear which of these features are truly driven by aging processes. Moreover, virtually all of these studies have focused on chronological aging. However, recent innovative approaches in other disciplines have begun to explore the concept of "biological aging" as a better descriptor for risk of ...more »

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Commensal flora-immune system interactions

The commensal flora-immune system interactions that help to maintain oral health is an understudied area. The flexibility of the immune system related to the immunobiography and aging effects on this response repertoire clearly has a critical component of interactions with the commensal or autochthonous microbiome of an individual. We still know little regarding how commensal bacteria help program symbiotic immune responses, ...more »

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Efficacy of modern therapeutics against oral diseases.

As data has been gathered documenting roles for various host responses in the deleterious consequences of the persistent inflammation in periodontitis, as well as the unique feature of the resolution response biomolecules, modern tools for host response modulation (i.e., array of monoclonal antibody drugs for chronic inflammatory diseases) have generally not been evaluated related to periodontitis. If we are to increase ...more »

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Immune System Balance and Flexibility in Maintaining Good Oral Health

Submitted by (@sajiboye)

AADR: Immune hyperactivity in Sjögren's Syndrome

The specific areas of interest enumerated in the concept clearance would help advance research on Sjögren's Syndrome. The underlying reasons for immune hyperactivity in this disease are poorly understood. It is critical to understand what factors drive this pathologic activation in order to maintain immune homeostasis in these individuals.

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