More than 15 million root canals are performed yearly by disinfection and placement of a root filling. An alternative approach would regenerate the pulp-dentin complex using autologous post-natal mesenchymal stem cells (MSCs) with a resorbable scaffold.
Using glycopolymers to mimic the natural barrier function of mucins and the glycocalyx to improve protection for natural healing and support the environment for cell growth rather than apoptosis or necrosis.
A better understanding of the mechanisms that bacteria use to modulate oral mucosal responses to maintain health could provide new opportunities to develop preventive strategies based on auto-therapies. Thinking about host-microbes interactions in health as a dynamic (but not static) process will support this goal.
In this sense, a biofilm can act as a reservoir for the... more »
In a dry mouth, how do we ensure caries restoration lasts a long time? Can we develop non-invasive ways to remineralize and repair teeth?
A comprehensive definition of hard and soft oral and craniofacial tissue health needs to be defined with deviations that are considered "healthy". Once criteria exists, it will be easier to determine disease state in these tissues.
The idea is to trigger the endogenous regenerative program after an injury by manipulating target gene expression level. Need to identify the genetic targets for increasing endogenous tissue renewal to aid in endogenous repairing.
The local tissue microenvironment can determine the success or failure of regenerative approaches, but much more needs to be discovered about how local extracellular matrix and bound signaling components can influence regenerative approaches. Applying future insights from embryonic development to modify local microenvironments and niches could facilitate successful regeneration.