National Institute of Dental and Craniofacial Research Precision Health

I was diagnosed with Follicular Lymphoma after more than a year of horrible pain, tooth loss and many antibiotic treatments for abscesses. This disease was and is rare and very little is known. Had I found out earlier exactly what I had, I may not have lost all my teeth and would not be without teeth currently. Cant wear dentures and I have no bone for implants. Something has to be figured out soon before another goes... more »

periodontal disease research is predominately focused on bacterial infections. In fact, genetics factor is a critical issue.

Global disease causing deaths in developed and developing countries. Its early identification is a need in dental clinics by dental practitioners. This enables dentist to refer a patient to the specialist care and hence managing the disease condition effectively.

FDA recently approved balloon dilation of Eustachian tube for companies Acclarent and Entellus. Cholesteatoma is a chronic disease process that requires long-term care and can often recur. Balloon dilation has already shown to allow improved aeration of the middle ear based on tympanogram evaluations. If this is true, it is hypothesized balloon dilation could improve outcomes and frequency of operations required for cholesteatoma.... more »

My main aim is to improve the methods of local treatment and to optimize the methods of the third prophylaxis of opportunistic lesions in the oral cavity which depend on clinical manifestations and special quality/peculiarity of microbiocenosis of the oral cavity in HIV-infected patients. Also my work designed to show the morbidity of opportunistic infections in the oral cavity and high incidence of periodontal diseases... more »

The infection control protocols regarding dental care in the portable unit setting (specifically schools) are vague. There seem to be two acceptable protocols - double wipe disinfection or disinfection plus barriers. I find no studies regarding specifics - does double-wipe remove adequately the microorganisms around the air-water syringe buttons? On suction levers?

1. Genetic healthiology: Gene defect or gene weakness make an individual has predisposition or vulnerable in some part of body. Quantitative measurement of such defect/weakness can help to adapt to the exist predisposition before any disease comes out.
2.genetic geriatrics. Due to gene defect/weakness, organs aging at different speed. Proper quantitative diagnoses and management of such defect/weakness can be preventive,... more »

Assemble, catalog, create database to incorporate medicinal facts and biological functions of every western and TRADITIONAL medicine, biological and chemical agent that has been used in treating dental and craniofacial diseases. In addition, repositories should be created to store them and that can also be used as the immediate resource for dentists and dental researchers.

Develop effective methods to prevent periodontal diseases – need to determine what the 22nd century preventive model will be. This would impact the entire education system as well.

Mercury is considered as a useful material in restorative dentistry. However, concern about the adverse effects of its disposal on the environment as a results of using it in health education environments has caused some countries to ban or reduce its use.

we introduced a method and its procedures, invented a mercury recycling device, and evaluated our proposed method.

Penetrance and severity of dental and craniofacial defects are highly variable, even between patients and mice carrying the same genetic mutation. Little is known about causes of this variability. Establishing modifiers of dental and craniofacial disease severity using mouse models could provide important translational knowledge for application to patients. I suggest a call for proposals that work to establish genetic,... more »

Hypothesis: ACEs scores and/or social determinants of health can predict the incidence of TMJ/TMD over the lifespan.

Test genetic mutants in saliva to understand saliva's role in oral tissue regeneration or prevention of oral cancer.

Based on personal experience and observations, it seems that gingival recession is highly prevalent, and the cause is not always as easily identified as dentists seem to think.. The fix is not simply to "use a softer toothbrush". It can also be related to clenching of jaws that impart high forces on teeth, etc.. Mouth-guards are used, but they are designed to protect teeth from grinding, and this design does not properly... more »

Choropleth mapping should be introduced in the field of dentistry. These thematic maps can be used to cover all oral disease in a country and will give a idea of which territories should be focused on for particular oral disease and appropriate preventive measures can be planned.