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Precision Health

Precision Immunotherapy for Oral Cancer

The NIH Funding to Incidence Ratio for Oral Cancer is the lowest among the studied cancer types ($785 for oral cancer as opposed to $2,902 for Breast Cancer). But the incidence of HPV+ Oral Cancer has been projected to increase until 2060. Immunotherapy has shown great promise. But the OC patient response to checkpoint inhibition is low. Future research programs to characterize immunosuppression in oral cancer and to... more »
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Precision Health

Neural circuitry underlying orofacial neuropathic pain

Orofacial neuropathic pain, such as trigeminal neuralgia, is a debilitating neurological disorder and represents a challenge to dentists and pain specialists. Currently the mechanisms for the development of orofacial neuropathic pain are not fully understood and available treatment strategies are inadequate. Unraveling central neural circuitry underlying the pathogenesis of orofacial neuropathic pain will help us develop... more »
(@chasclendenen) kudos icon +

Precision Health

Treatment of Oral/Facial Deformity in Neurofibromatosis Patients

My grandson is an NF Plexiform type 1 Patient. He and other children with NF have anywhere from mild to severe facial deformities. I am submitting a request for NF to be put on the NIDCR "radar" for research, clinical trials, and treatment options.

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Precision Health

Precision Dentistry in Managing Genetic Related Oral Diseases

The periodontal disease , Oral Cancer, Dental Caries, Cleft Lip & Cleft Palate,Malocclusion, Amelogenesis Imperfecta and Dentinogenesis Imperfecta are genetic related diseases that manifest in the oral cavity and dentition and run in the families. Precision medicine in 2016 has taken an initiative to prepare treatment that are customised to patient needs. It helps in identifying target gene and helps to develop a more... more »
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Precision Health

Dissecting Intratumoral Heterogeneity of Head and Neck Cancers

While we are still benefiting from projects like The Cancer Genome Atlas, more information about genetic/pathway alterations in each tumor is still required to better treat our patients. New technologies to dissect each tumor will provide vital information to more effectively treat each patient by aiding clinicians in selecting therapies targeting 1) major altered pathways, 2) identified stem cells and progenitor cell,... more »
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Precision Health

Diagnostic Precision in Caries Risk Assessment Via CALIBRATION

There are abundant examples in the literature illuminating the relative discordance to be found when assessing diagnostic agreement (and, lack thereof) between dental providers. This data should not be left as an unaddressed observation only.
Shared images: both radiographic and clinical may be used globally to better achieve concordance and calibration with this, perhaps, leading to the more rapid inclusion of less... more »
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Precision Health

Impact of tumor heterogeneity on personalized and immunotherapy

Intra-tumor genetic heterogeneity, the set of differences in mutations among a tumor’s cancer cells, is a major obstacle to successful therapy. if a target of therapy is not in all subclones, or an immune response is activated only against subclonal neoantigens, only the subclones that contain the target or those neoantigens will respond directly. If mutations in a subclone make it resistant to therapy, that resistant... more »