Over the past decade, NIDCR has invested in the development of specimens and preclinical models of salivary gland cancers, as well as their genomic characterization. The field is now ripe for translating the significantly expanded basic biological understanding and preclinical models into new therapeutics. Phenotypic and target-based drug discovery can lead to rational clinical trials for these tumor types which have ...more »
Precision prevention, treatment, and public health interventions will be available to all people based on their unique variations in genetic, biological, behavioral, and social determinants of health. Individual and population-based dental, oral, and craniofacial prevention and treatment strategies will be scientifically-based and validated.
Please submit your ideas on what it will take to reach this goal.
We need a targeted funding announcement that brings health care systems with integrated oral health care and a common medical record into the national cohort
Newborns, particularly those born prematurely, are the ideal population for the development of targeted salivary assays to monitor health, development and disease. Their overall vulnerability, combined with their limited blood volumes, mandates that strategies be developed that incorporate alternative biofluids to monitor their health status. Interrogation of neonatal salivary 'omic' profiles provides an important opportunity ...more »
There are large disparities in dental caries prevalence and incidence across the lifespan. Precision health requires identification of valid risk markers of disease, so that risk-based protocols can be implemented. We desperately need research on the effectiveness and cost-effectiveness of risk-based protocols for caries management across the lifespan.
More studies (epidemiological and clinical data oriented) correlating economic disparities in the US and oral health related to overall health issues will be warranted. Certain US geographical regions with depressed economic scenario and populations with adverse economic backgrounds (African-American, Native American, Hispanics, etc) might have to be considered. Prevention measures to oral diseases and possible treatment ...more »
We need a greater focus on pragmatic (effectiveness) trials in oral health care settings. This desperately needed so we can develop interventions that are feasible in clinical settings and have a high probability of being more broadly implemented.
Studies on how social determinants affect oral health and which in turn results in inequitable oral health are less studied in developed countries and yet to be started in developing countries. We try to understand and measure different structural determinants and intermediate determinants affecting oral health i.e. the cause of all causes in oral diseases and try to implement different intervention to successfully reduce ...more »
Precision public health & precision population health (Khoury, 2016) are vital for precision health to create precision prevention, since 1/3 of mortality is preventable thru modifying social disparities in health (eg tobacco use, low physical activity, poor nutrition). Neighborhood- (eg census tract tobacco use prevalence and census tract air quality reports) and individual-level data (eg nicotine metabolic rate) could ...more »
Vaccines remain one of the most potent infectious disease prevention tools. The discovery of the oral microbiome has demonstrated that communities of bacteria are critical to maintaining oral health and the development of oral disease. However, keystone species of bacteria often play a disproportionately large role in oral disease (e.g. S. mutans in caries). Oral disease vaccines could be effective in prevention and/or ...more »
Support and advance translational research designed to identify and overcome barriers to the adoption and delivery of known effective preventive and therapeutic interventions.
Instead of building interventions that target identified causal mechanisms of DOC disorder, including oral health disparities, the current state of BSSR draws on descriptive and correlational data to build complex, multi-level interventions intended to address as many possible drivers of DOC disorder as possible. Building interventions that test how and for whom interventions produce their effects, in addition to whether ...more »
Oral microbiome is a reflection of the host's physiological state and is highly dynamic. Dysbiosis is often associated with disease conditions. A program for systematic and periodic tracking the oral microbiome state of subjects will allow for effective means to detect relevant changes in microbiome state towards dysbiosis. This will enable strategies for early detection of oral and general health problems.