Accelerating the Development of Oral Biodevices by Advancing Technologies

Accelerating the Development of Oral Biodevices by Advancing Technologies

Oral biodevices that monitor oral and overall health, detect and treat disease, and aid in clinical decision making could significantly advance mobile health technology. The goal of this initiative is to speed the translation of oral biodevices from the laboratory into the clinic.

View submitted comments relating to this proposed research initiative. Click on "more details," below, for the full description.

FULL DESCRIPTION

Wearable biosensor technologies such as smart watches, activity trackers, and glucose monitors can record the number of steps you take, your heart rate and sleep patterns, and your blood glucose levels. Since the mouth provides ready access to the oral cavity and the whole body, biodevices specifically developed to function within the oral cavity could take advantage of existing and new technologies to monitor many aspects of oral and overall health, detect and treat disease, and aid in clinical decision making. However, there are unique challenges to surmount for enabling the development of clinically useful oral biodevices. For example, an oral biodevice should be able to stick to wet tissues and be resilient to handle harsh and repetitive exposures to varying chewing forces, pH levels, temperatures, enzymes, and bacteria present in the mouth. Therefore, the goal of this initiative is to encourage transformative engineering solutions to challenges imposed by the oral environment to speed the translation of oral biodevices from the laboratory to the clinic.

Potential research areas include development of oral biodevices with ability for real-time measurements and secured wireless data transmission; improved power sources and computing software; ability to deliver drugs or other therapeutics in response to changes detectable in the oral environment; integration of oral biodevices with other mobile technologies; and improved durability, safety, and accuracy. Accelerating oral biodevice research is a key step in making precision medicine a reality, by empowering individuals and their healthcare providers with accurate health data to tailor individual treatment and prevention strategies for a wide variety of diseases and conditions affecting the mouth and the whole body.