Over the past decade, NIDCR has invested in the development of specimens and preclinical models of salivary gland cancers, as well as their genomic characterization. The field is now ripe for translating the significantly expanded basic biological understanding and preclinical models into new therapeutics. Phenotypic and target-based drug discovery can lead to rational clinical trials for these tumor types which have... more »
Precision prevention, treatment, and public health interventions will be available to all people based on their unique variations in genetic, biological, behavioral, and social determinants of health. Individual and population-based dental, oral, and craniofacial prevention and treatment strategies will be scientifically-based and validated.
View submitted ideas on what it will take to reach this goal.
We need a targeted funding announcement that brings health care systems with integrated oral health care and a common medical record into the national cohort
Newborns, particularly those born prematurely, are the ideal population for the development of targeted salivary assays to monitor health, development and disease. Their overall vulnerability, combined with their limited blood volumes, mandates that strategies be developed that incorporate alternative biofluids to monitor their health status. Interrogation of neonatal salivary 'omic' profiles provides an important opportunity... more »
Orofacial neuropathic pain, such as trigeminal neuralgia, is a debilitating neurological disorder and represents a challenge to dentists and pain specialists. Currently the mechanisms for the development of orofacial neuropathic pain are not fully understood and available treatment strategies are inadequate. Unraveling central neural circuitry underlying the pathogenesis of orofacial neuropathic pain will help us develop... more »
The NIH Funding to Incidence Ratio for Oral Cancer is the lowest among the studied cancer types ($785 for oral cancer as opposed to $2,902 for Breast Cancer). But the incidence of HPV+ Oral Cancer has been projected to increase until 2060. Immunotherapy has shown great promise. But the OC patient response to checkpoint inhibition is low. Future research programs to characterize immunosuppression in oral cancer and to... more »
Vaccines remain one of the most potent infectious disease prevention tools. The discovery of the oral microbiome has demonstrated that communities of bacteria are critical to maintaining oral health and the development of oral disease. However, keystone species of bacteria often play a disproportionately large role in oral disease (e.g. S. mutans in caries). Oral disease vaccines could be effective in prevention and/or... more »
Instead of building interventions that target identified causal mechanisms of DOC disorder, including oral health disparities, the current state of BSSR draws on descriptive and correlational data to build complex, multi-level interventions intended to address as many possible drivers of DOC disorder as possible. Building interventions that test how and for whom interventions produce their effects, in addition to whether... more »
Oral microbiome is a reflection of the host's physiological state and is highly dynamic. Dysbiosis is often associated with disease conditions. A program for systematic and periodic tracking the oral microbiome state of subjects will allow for effective means to detect relevant changes in microbiome state towards dysbiosis. This will enable strategies for early detection of oral and general health problems.
There is a growing body of research on behavioral change interventions in healthcare, education and financial domains. These interventions utilize general tools such as providing education on temptation bundling. Smartphones and wearables provide a unique platform for continuous monitoring and micro-interventions in a personalized manner. Research in the most effective use of these technologies in establishing positive... more »
There are large disparities in dental caries prevalence and incidence across the lifespan. Precision health requires identification of valid risk markers of disease, so that risk-based protocols can be implemented. We desperately need research on the effectiveness and cost-effectiveness of risk-based protocols for caries management across the lifespan.
Promote studies on the pathogenesis of dental caries, periodontal diseases and oral cancer to advance precision health and establish foundational knowledge for risk-based prevention and therapies.
We need to capitalize on the existing self-setting ceramic bioactive materials to increase the success of pulp therapy & regenerative therapy, reduce root canal failure, reduce root fracture or improve repair of fractured roots. Develop bioactive ceramic materials that would be effective at treating periodontal and cervical resorptive defects. Develop bioactive ceramic materials that would be effective at ridge augmentation.... more »
By sponsoring dental continuing-education regional symposiums that disseminate scientifically-based and validated treatment strategies for different rare disease populations, the NIDCR could play a leading role in improving the clinical care of rare disease patients.
While we are still benefiting from projects like The Cancer Genome Atlas, more information about genetic/pathway alterations in each tumor is still required to better treat our patients. New technologies to dissect each tumor will provide vital information to more effectively treat each patient by aiding clinicians in selecting therapies targeting 1) major altered pathways, 2) identified stem cells and progenitor cell,... more »
In a dry mouth, can we find better ways to identify, prevent and control rampant yeast infection?