Compromised oral and dental health in non communicable diseases(NCDs) such as diabetes, liver cirrhosis, advance kidney failure etc is documented in literature but HIV along with NCDs status is again great area which needs to be explored. Due to major organ failures, least importance is given to oral health problems nowdays leading to its increased severity, with cases terminating into oral malignancies also. I would ...more »
AADR strongly and enthusiastically supports this proposed initiative. AADR commends NIDCR for its efforts to increase the diversity of the dental, oral and craniofacial research workforce. AADR members have provided the following feedback and recommendations: Look to the National Research Mentoring Network (NRMN) for programmatic elements and metrics for assessing the impact of the network and success of participants. ...more »
NIDCR initiative of giving better representation and improved networking to early career researchers will be very instrumental and a prudent step in long run. This will give more opportunity to enthusiastic and knowledge seeking young professionals to hone and upgrade their skills and use them for under represented regions . It is also great that experienced and senior faculty "pass the baton " to young guns for promising ...more »
Dear NIDCR, thank you for the opportunity. I think its a right step in the right direction. The ultimate of which should lead to adequate care and wellbeing of the larger society. Thank you.
Dear NIDCR, Thank you for creating this opportunity to share our experiences and suggest topics for mentorship. As an URM postdoctoral faculty, I absolutely love the seminars that you have suggested. Personally, I wish I could learn about how to search for grants, grant writing and submission, research methodologies, leadership development, and mentorship. I think if you could create some webinars for these topics, or ...more »
Dear NIDCR, Thank you so much for your Initiative. Idea of mentoring Network for Underrepresented Postdoctoral and Early-Career Faculty Investigators is very novel and innovative idea. I believe if Early-Career Faculty Investigators from Underrepresented area must be given opportunity for learning in conventional and new areas of oral and dental care to serve the people the that region without compromising the quality ...more »
While work on immune responses in the oral cavity and studies of periodontitis have demonstrated changes with aging, it is not clear which of these features are truly driven by aging processes. Moreover, virtually all of these studies have focused on chronological aging. However, recent innovative approaches in other disciplines have begun to explore the concept of "biological aging" as a better descriptor for risk of ...more »
The immune system is constructed to enable a very broad, almost infinite ability to respond to antigenic challenges, including those derived from the oral microbiome related to periodontitis and caries. This concept has been described as the immunobiography of each individual and is a composite of challenges and responses early in life that may program the immune system for the characteristics of responses later in life. ...more »
As data has been gathered documenting roles for various host responses in the deleterious consequences of the persistent inflammation in periodontitis, as well as the unique feature of the resolution response biomolecules, modern tools for host response modulation (i.e., array of monoclonal antibody drugs for chronic inflammatory diseases) have generally not been evaluated related to periodontitis. If we are to increase ...more »
The commensal flora-immune system interactions that help to maintain oral health is an understudied area. The flexibility of the immune system related to the immunobiography and aging effects on this response repertoire clearly has a critical component of interactions with the commensal or autochthonous microbiome of an individual. We still know little regarding how commensal bacteria help program symbiotic immune responses, ...more »
The antigenic ecospace can be defined as "the universe of antigens that [have] driven [immune system] evolution.(1) How this ecospace changes on the individual level during the initiation and progression of disease, such as periodontitis, and how the individual host immune capacity reacts to these changes remains ill-defined. Reference 1. Capri M, Salvioli S, Monti D, Bucci L, Garagnani P, Ottaviani E, Franceschi C. ...more »
The specific areas of interest enumerated in the concept clearance would help advance research on Sjögren's Syndrome. The underlying reasons for immune hyperactivity in this disease are poorly understood. It is critical to understand what factors drive this pathologic activation in order to maintain immune homeostasis in these individuals.