Embryonic tissues and organs can often effectively compensate for defects during development, but how they do so is poorly understood. Applying strategies used by embryos to adults could lead to novel autotherapies.
The local tissue microenvironment can determine the success or failure of regenerative approaches, but much more needs to be discovered about how local extracellular matrix and bound signaling components can influence regenerative approaches. Applying future insights from embryonic development to modify local microenvironments and niches could facilitate successful regeneration.
The idea is to trigger the endogenous regenerative program after an injury by manipulating target gene expression level. Need to identify the genetic targets for increasing endogenous tissue renewal to aid in endogenous repairing.
In a dry mouth, how do we ensure caries restoration lasts a long time? Can we develop non-invasive ways to remineralize and repair teeth?
In this sense, a biofilm can act as a reservoir for the... more »
More than 15 million root canals are performed yearly by disinfection and placement of a root filling. An alternative approach would regenerate the pulp-dentin complex using autologous post-natal mesenchymal stem cells (MSCs) with a resorbable scaffold.
A better understanding of the mechanisms that bacteria use to modulate oral mucosal responses to maintain health could provide new opportunities to develop preventive strategies based on auto-therapies. Thinking about host-microbes interactions in health as a dynamic (but not static) process will support this goal.
A comprehensive definition of hard and soft oral and craniofacial tissue health needs to be defined with deviations that are considered "healthy". Once criteria exists, it will be easier to determine disease state in these tissues.