(@jmaron) kudos icon +

Precision Health

Neonatal Salivary 'Omic' Research

Newborns, particularly those born prematurely, are the ideal population for the development of targeted salivary assays to monitor health, development and disease. Their overall vulnerability, combined with their limited blood volumes, mandates that strategies be developed that incorporate alternative biofluids to monitor their health status. Interrogation of neonatal salivary 'omic' profiles provides an important opportunity... more »
(@trisha) kudos icon +

Precision Health

RDH, the Oral Health Coach

The brush-floss-fluoride message isn’t working. Dental disease is still a significant problem for all age groups and getting worse. Let's take prevention out of the dental office and to the people where they live and work. Coaching kids to play soccer with just two 45-minute practices each year doesn't work, so why do we think twice yearly visits to the dental office will successfully coach people in all they need... more »
(@paultrainor) kudos icon +

Precision Health

Prevention of Craniofacial Birth Defects

Craniofacial birth defects prevention and sensible approaches to designing preventative therapies is rarely afforded the attention it deserves. The potential for prevention is too often drowned out by the noise surrounding stem cells, re-programming and tissue engineering. Each of these approaches has merit in their own right, but equal attention should be given to prevention.

(@novincec) kudos icon +

Precision Health

Preventative Protocols Optimizing Peri-Implant Health

Advances in endosseous implant technology have resulted in the implant becoming a common replacement in dental practices. Despite knowledge that dental implants are susceptible to plaque biofilm induced peri-implant disease states, there are no established guidelines for preventative care in the implant patient. Research advancing knowledge about personal and professional debridement measures optimizing peri-implant... more »
(@thatisaok) kudos icon +

Precision Health

Optimizing Self Care for Periodontal Disease Patients

Research the best self care protocol for periodontal disease Patients are told to brush and floss 2X a day, and possibly to rinse with mouthwash and/or hydrogen peroxide, along with possibly using water flossers and special brushes and picks to clean between teeth. That advice is not much different from what patients without periodontal disease are told to do. I want my routine to be optimally effective,given that... more »
(@james.rocco) kudos icon +

Precision Health

Impact of tumor heterogeneity on personalized and immunotherapy

Intra-tumor genetic heterogeneity, the set of differences in mutations among a tumor’s cancer cells, is a major obstacle to successful therapy. if a target of therapy is not in all subclones, or an immune response is activated only against subclonal neoantigens, only the subclones that contain the target or those neoantigens will respond directly. If mutations in a subclone make it resistant to therapy, that resistant... more »
(@byrdkm) kudos icon +

Precision Health

Dissecting Intratumoral Heterogeneity of Head and Neck Cancers

While we are still benefiting from projects like The Cancer Genome Atlas, more information about genetic/pathway alterations in each tumor is still required to better treat our patients. New technologies to dissect each tumor will provide vital information to more effectively treat each patient by aiding clinicians in selecting therapies targeting 1) major altered pathways, 2) identified stem cells and progenitor cell,... more »
(@nhatch) kudos icon +

Precision Health

Modifiers of Dental and Craniofacial Disorders

Penetrance and severity of dental and craniofacial defects are highly variable, even between patients and mice carrying the same genetic mutation. Little is known about causes of this variability. Establishing modifiers of dental and craniofacial disease severity using mouse models could provide important translational knowledge for application to patients. I suggest a call for proposals that work to establish genetic,... more »
kudos icon +

Precision Health

recycle amalgam mercury

Mercury is considered as a useful material in restorative dentistry. However, concern about the adverse effects of its disposal on the environment as a results of using it in health education environments has caused some countries to ban or reduce its use.

we introduced a method and its procedures, invented a mercury recycling device, and evaluated our proposed method.

(@nisan.b) kudos icon +

Precision Health

Create Resource Guide for Dentists and Dental Researchers

Assemble, catalog, create database to incorporate medicinal facts and biological functions of every western and TRADITIONAL medicine, biological and chemical agent that has been used in treating dental and craniofacial diseases. In addition, repositories should be created to store them and that can also be used as the immediate resource for dentists and dental researchers.