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Oral Health + Overall Health

Oral Health and Aging

Research addressing the oral health of the aging population is urgently needed. The US “65-and-over population is projected to nearly double over the next three decades, from 48 million to 88 million by 2050” (National Institute of Aging). According to the 2011-2012 National Health and Nutrition Examination Survey, 25% of adults 75 and older were edentulous. NIDCR should prioritize research on the impact of aging on care... more »
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Oral Health + Overall Health

Polymicrobial synergy

Oral diseases (as well as most other inflammatory diseases of the mucosae) are known to be triggered by the immunopathology resulting from the overabundance of particular combinations of species in the flora. There are now numerous microbiome studies of different inflammatory diseases, and it is becoming clear which species are associated with each of these diseases. However, extremely little is known about the mechanisms... more »
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Oral Health + Overall Health

Link basic and applied periodontal disease/caries research

Some members of the dental community have expressed concern that periodontal disease and dental caries do not receive adequate research funding. However in AADR’s view, this concern is not being inclusive of the basic research findings that can be applied to the understanding, prevention and treatment of these diseases even though the specific aims of the project do not directly address periodontal disease and dental... more »
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Oral Health + Overall Health

The Relationship between Swallowing Function and Oral Health

Swallowing, oral health, and saliva production are crucial factors for maintaining overall health and an optimal quality of life. While evidence suggests that these factors are inter-related in both health and disease, there is a paucity of evidence that has explored these factors and their potential relationships. Generating new knowledge of these factors and the relationships between them has the potential to positively... more »
(@lstrup13) kudos icon +

Oral Health + Overall Health

Very Little Related to Craniofacial Research or Diseases

There is little related to craniofacial research or diseases. Most of the goals relate to oral and dental health. It may be that this area should be attached to NIAMS and dropped from NIDCR, but then it should be done officially so that non-oral/dental researchers and clinicians find appropriate support.

(@lstrup13) kudos icon +

Oral Health + Overall Health

Few Opportunities for Basic Science Research

There appears to be few opportunities for basic science research other than under the “Oral Health + Overall Health” block where ‘the understanding of the underlying biological cause of disease’ is clearly mentioned. Although this can be a topic of intense basic science research, the Institute should provide some kind of disease priorities based on incidence/epidemiology and cost to society.

(@natian) kudos icon +

Oral Health + Overall Health

Adding oral microbiota information to DNA testing

Human whole saliva contains multiple components such as salivary proteins, epithelial cell exfoliated from mucosa, dietary components as well as oral microorganisms. Some biotech start-up companies, such as 23andme, use saliva samples to provide human genetic information (DNA) to populations. Data about Oral microbiota can be also acquired in saliva samples, and such information may be as important as human DNA information... more »
(@natian) kudos icon +

Oral Health + Overall Health

Oral cavity and Nutrition

Salivary constituents including oral microorganisms can reach the lower gastrointestinal tract. Saliva and oral microbes contain various enzymes. Some of those enzymes exhibit the ability to process food. Thus salivary constituents may affect the procession and absorption of the dietary components. The understanding of oral cavity components on food procession is lacking but important for understanding the relation between... more »
(@shiyuwang) kudos icon +

Oral Health + Overall Health

The effect of VDO loss or under develpment on general health.

TMJ diseases, sleep apnea, and other health problem are related to the loss of vertical dimension of occlusion(VDO). Even aging may be due to VDO loss which causing gradual narrowing of air passway. I use loss vs. decrease because VDO loss is the best word to describe the problem, wether it is due to teeth wear out or due to under growth of lower jaw( stress -growth H secretion during night-under growth of lower jaw).... more »
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Oral Health + Overall Health

Developing a new class of analgesics to treat pain

Currently, between aspirin and morphine there are no better options to treat chronic pain! One of the viable approach is to identify and validate kinase inhibitors as potential new class of analgesics. There are many kinases known to be involved in modulating pain and their systematic study will be valuable towards this goal

(@ben.werth) kudos icon +

Oral Health + Overall Health

Obstructive Sleep Apnea, dental health and overall well being

Obstructive Sleep Apnea (OSA) has detrimental effects on oral health (dental carries, gum recession) as well as overall health (Migraines, lethargy, cardio vascular disease, and possible depression/anxiety). Why is OSA so common? Is it a 21st century problem, or human genetics? What are possible cures, remedies or therapies other than the single, but trustworthy, CPAP machine?
From my own personal experience, Myofunctional... more »
(@lecmn7) kudos icon +

Oral Health + Overall Health

Subspecialty in post-radiation care

With new medical advances in oncology, immunology and genetics, people are living longer after radiation therapy. Regenerative medicine is not appropriate for these folks as they are working to prevent new cancer growth. In my case, I have mucosal melanoma of the hard palate and am 5 years RT. I have extensive oral care and see the dentist for cleanings every few months. Still, I have exposed tooth roots as well as ORN... more »