Other topics that may fit within this proposed research initiative include oral effects of addictive or risky behaviors (e.g. video games and computer usage, risky sexual behaviors, piercing and self-mutilation, etc.) and the use of other drugs and alcohol. Research on marijuana is especially timely as state and local governments move towards decriminalization and legalization for recreational or medical purposes. These ...more »
AADR applauds NIDCR's previous investments in e-cigarette research and encourages continued investment in this area. According to Food and Drug Administration Commissioner Scott Gottlieb, e-cigarette use among adolescents has reached "epidemic" levels. (1) E-cigarettes are the most popular tobacco product used by middle and high school students, and there is evidence that e-cigarettes may lead adolescents who never would ...more »
According to the National Comorbidity Survey Replication, the median age of onset of bulimia is 18 (1), so specific inclusion of oral health research on bulimic patients would be wise. A recent systematic review identified several oral health manifestations of bulimia. In particular, specific patterns of tooth erosion can be the first visible indicators of bulimia, so dentists and hygienists can have a crucial role in ...more »
The concept clearance defines adolescence from ages 12-19. Some individuals in this age range attend college. Cutting adolescence off at age 19 may be in the middle of their college careers, which would be somewhat arbitrary. A broader range, up to age 21, would be helpful.
The specific areas of interest enumerated in the concept clearance would help advance research on Sjögren's Syndrome. The underlying reasons for immune hyperactivity in this disease are poorly understood. It is critical to understand what factors drive this pathologic activation in order to maintain immune homeostasis in these individuals.
As data has been gathered documenting roles for various host responses in the deleterious consequences of the persistent inflammation in periodontitis, as well as the unique feature of the resolution response biomolecules, modern tools for host response modulation (i.e., array of monoclonal antibody drugs for chronic inflammatory diseases) have generally not been evaluated related to periodontitis. If we are to increase ...more »
The commensal flora-immune system interactions that help to maintain oral health is an understudied area. The flexibility of the immune system related to the immunobiography and aging effects on this response repertoire clearly has a critical component of interactions with the commensal or autochthonous microbiome of an individual. We still know little regarding how commensal bacteria help program symbiotic immune responses, ...more »
While work on immune responses in the oral cavity and studies of periodontitis have demonstrated changes with aging, it is not clear which of these features are truly driven by aging processes. Moreover, virtually all of these studies have focused on chronological aging. However, recent innovative approaches in other disciplines have begun to explore the concept of "biological aging" as a better descriptor for risk of ...more »
The antigenic ecospace can be defined as "the universe of antigens that [have] driven [immune system] evolution.(1) How this ecospace changes on the individual level during the initiation and progression of disease, such as periodontitis, and how the individual host immune capacity reacts to these changes remains ill-defined. Reference 1. Capri M, Salvioli S, Monti D, Bucci L, Garagnani P, Ottaviani E, Franceschi C. ...more »
The immune system is constructed to enable a very broad, almost infinite ability to respond to antigenic challenges, including those derived from the oral microbiome related to periodontitis and caries. This concept has been described as the immunobiography of each individual and is a composite of challenges and responses early in life that may program the immune system for the characteristics of responses later in life. ...more »
On behalf of colleagues at the UCSF Center to Address Disparities in Oral Health (known as CAN DO), thanks for the chance to provide input. Overall, we support the "Interdisciplinary Approaches to Promote Adolescents' Oral Health and Reduce Disparities" initiative since adolescence is such an important period in the lifecourse for establishing healthy behaviors and learning to self-manage health. We agree that research ...more »
Compromised oral and dental health in non communicable diseases(NCDs) such as diabetes, liver cirrhosis, advance kidney failure etc is documented in literature but HIV along with NCDs status is again great area which needs to be explored. Due to major organ failures, least importance is given to oral health problems nowdays leading to its increased severity, with cases terminating into oral malignancies also. I would ...more »