Precision Health

Precision Health

Precision prevention, treatment, and public health interventions will be available to all people based on their unique variations in genetic, biological, behavioral, and social determinants of health. Individual and population-based dental, oral, and craniofacial prevention and treatment strategies will be scientifically-based and validated.

View submitted ideas on what it will take to reach this goal.

Showing 17 ideas for tag "oral-cancer"
(@jeffrey) kudos icon +

Precision Health

Therapeutics for Salivary Gland Cancers

Over the past decade, NIDCR has invested in the development of specimens and preclinical models of salivary gland cancers, as well as their genomic characterization. The field is now ripe for translating the significantly expanded basic biological understanding and preclinical models into new therapeutics. Phenotypic and target-based drug discovery can lead to rational clinical trials for these tumor types which have... more »
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Precision Health

Precision Immunotherapy for Oral Cancer

The NIH Funding to Incidence Ratio for Oral Cancer is the lowest among the studied cancer types ($785 for oral cancer as opposed to $2,902 for Breast Cancer). But the incidence of HPV+ Oral Cancer has been projected to increase until 2060. Immunotherapy has shown great promise. But the OC patient response to checkpoint inhibition is low. Future research programs to characterize immunosuppression in oral cancer and to... more »
(@jonathan.horsford) kudos icon +

Precision Health

Develop Oral Disease Vaccines

Vaccines remain one of the most potent infectious disease prevention tools. The discovery of the oral microbiome has demonstrated that communities of bacteria are critical to maintaining oral health and the development of oral disease. However, keystone species of bacteria often play a disproportionately large role in oral disease (e.g. S. mutans in caries). Oral disease vaccines could be effective in prevention and/or... more »
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Precision Health

Behavior change interventions that target causal mechanisms

Instead of building interventions that target identified causal mechanisms of DOC disorder, including oral health disparities, the current state of BSSR draws on descriptive and correlational data to build complex, multi-level interventions intended to address as many possible drivers of DOC disorder as possible. Building interventions that test how and for whom interventions produce their effects, in addition to whether... more »
(@murat.sincan) kudos icon +

Precision Health

personalized behavioral change interventions

There is a growing body of research on behavioral change interventions in healthcare, education and financial domains. These interventions utilize general tools such as providing education on temptation bundling. Smartphones and wearables provide a unique platform for continuous monitoring and micro-interventions in a personalized manner. Research in the most effective use of these technologies in establishing positive... more »
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Precision Health

Bioactive ceramics

We need to capitalize on the existing self-setting ceramic bioactive materials to increase the success of pulp therapy & regenerative therapy, reduce root canal failure, reduce root fracture or improve repair of fractured roots. Develop bioactive ceramic materials that would be effective at treating periodontal and cervical resorptive defects. Develop bioactive ceramic materials that would be effective at ridge augmentation.... more »
(@byrdkm) kudos icon +

Precision Health

Dissecting Intratumoral Heterogeneity of Head and Neck Cancers

While we are still benefiting from projects like The Cancer Genome Atlas, more information about genetic/pathway alterations in each tumor is still required to better treat our patients. New technologies to dissect each tumor will provide vital information to more effectively treat each patient by aiding clinicians in selecting therapies targeting 1) major altered pathways, 2) identified stem cells and progenitor cell,... more »
(@stuart.gansky) kudos icon +

Precision Health

Precision Public Health to Avoid Increasing Health Disparities

Precision public health & precision population health (Khoury, 2016) are vital for precision health to create precision prevention, since 1/3 of mortality is preventable thru modifying social disparities in health (eg tobacco use, low physical activity, poor nutrition). Neighborhood- (eg census tract tobacco use prevalence and census tract air quality reports) and individual-level data (eg nicotine metabolic rate) could... more »
(@trisha) kudos icon +

Precision Health

RDH, the Oral Health Coach

The brush-floss-fluoride message isn’t working. Dental disease is still a significant problem for all age groups and getting worse. Let's take prevention out of the dental office and to the people where they live and work. Coaching kids to play soccer with just two 45-minute practices each year doesn't work, so why do we think twice yearly visits to the dental office will successfully coach people in all they need... more »
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Precision Health

Economic Disparity in the US and Oral Health Issues

More studies (epidemiological and clinical data oriented) correlating economic disparities in the US and oral health related to overall health issues will be warranted. Certain US geographical regions with depressed economic scenario and populations with adverse economic backgrounds (African-American, Native American, Hispanics, etc) might have to be considered. Prevention measures to oral diseases and possible treatment... more »
(@chasclendenen) kudos icon +

Precision Health

Treatment of Oral/Facial Deformity in Neurofibromatosis Patients

My grandson is an NF Plexiform type 1 Patient. He and other children with NF have anywhere from mild to severe facial deformities. I am submitting a request for NF to be put on the NIDCR "radar" for research, clinical trials, and treatment options.

(@hopkinsaubrey4nidcr) kudos icon +

Precision Health

Diagnostic Precision in Caries Risk Assessment Via CALIBRATION

There are abundant examples in the literature illuminating the relative discordance to be found when assessing diagnostic agreement (and, lack thereof) between dental providers. This data should not be left as an unaddressed observation only.
Shared images: both radiographic and clinical may be used globally to better achieve concordance and calibration with this, perhaps, leading to the more rapid inclusion of less... more »
(@bpaniagua) kudos icon +

Precision Health

Use 3D image analysis to advance research and improve treatments

More translational research is needed to assess/improve current treatments and design new ones. Advances in medical computing can provide tools for this research. Data generated by 3D imaging techniques like CBCT or MRI are underutilized in dental research.
New algorithms for 3D dental images, disseminated via open source research tools, will help researchers learn about pathologies and assess treatment outcomes via... more »
(@thatisaok) kudos icon +

Precision Health

Optimizing Self Care for Periodontal Disease Patients

Research the best self care protocol for periodontal disease Patients are told to brush and floss 2X a day, and possibly to rinse with mouthwash and/or hydrogen peroxide, along with possibly using water flossers and special brushes and picks to clean between teeth. That advice is not much different from what patients without periodontal disease are told to do. I want my routine to be optimally effective,given that... more »
(@mayanktandon) kudos icon +

Precision Health

Oral Health Informatics Database

The body of knowledge in oral health is growing fast across diverse areas, including access to and quality of care, disease epidemiology, as well as clinical, molecular, and genetic profiling of populations. In order to glean actionable intelligence from these disparate data sources, integration, curation, and dissemination of the data is going to be critical. Both public and private research can benefit from a centralized... more »