Autotherapies

In situ cell reprogramming for DOC tissue regeneratiion

Develop approaches for generation of functional dental, oral and craniofacial (DOC) cell types by in situ reprogramming from other cell types available at a given tissue site. Examples of this kind of reprogramming are available in the literature: pancreatic endocrine beta-cells from pancreatic exocrine cells; cardiomyocytes and neurons from fibroblasts, among others. Although potentially very useful for regeneration of DOC tissues, this strategy has not been attempted for obtaining DOC cells.

Comment No. 116