In situ cell reprogramming for DOC tissue regeneratiion

Develop approaches for generation of functional dental, oral and craniofacial (DOC) cell types by in situ reprogramming from other cell types available at a given tissue site. Examples of this kind of reprogramming are available in the literature: pancreatic endocrine beta-cells from pancreatic exocrine cells; cardiomyocytes and neurons from fibroblasts, among others. Although potentially very useful for regeneration of DOC tissues, this strategy has not been attempted for obtaining DOC cells.