The immune system is constructed to enable a very broad, almost infinite ability to respond to antigenic challenges, including those derived from the oral microbiome related to periodontitis and caries. This concept has been described as the immunobiography of each individual and is a composite of challenges and responses early in life that may program the immune system for the characteristics of responses later in life. Much of the data in periodontitis has focused on the immunobiography that is expressed later in life, while we have little insight into early programming that enhances and detracts from immune system flexibility at the individual level. This immunobiography also represents features of immune memory (adaptive immune responses) and trained immunity (innate immune responses), albeit there exist rather limited data for the immunobiology of the oral cavity.
Comment No. 353